Emulate at Society of Toxicology 2024

Learn how you can confidently predict the human toxicity of drug candidates with Organ-Chips.

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EMULATE @ SOT 2024 | BOOTH #2122

Come see what we've been up to!

TALKS

Monday, March 11

  • 9:00 - 11:30 am: Can Microphysiological Systems Address Complex Toxicological Endpoints? (Room 255 D)

POSTERS

Monday, March 11

  • 9:15 - 11:15 am: Evaluating the immunotoxicity of CD137-induced agonism on the Human Liver-Chip (P612, Exhibit Hall C)
Tuesday, March 12
  • 2:15 - 4:15 pm: Donor-dependent responses to acetaminophen in human primary liver cells cultured in a liver microphysiological system (P723, Exhibit Hall C)

Wednesday, March 13

  • 11:45 am - 1:45 pm: On the potential of the Human Liver-Chip as a model of cholestatic toxicity (P495, Exhibit Hall C)

 

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Validated for DILI prediction

The Emulate human Liver-Chip is the first Organ-Chip to be qualified against IQ MPS guidelines for predicting drug-induced liver injury (DILI).

In a groundbreaking study, researchers demonstrated that the Emulate human Liver-Chip was able to correctly identify 87% of the tested drugs that caused DILI in patients despite passing animal testing evaluations.

At the same time, the Emulate human Liver-Chip did not falsely identify any drugs as toxic, leading to a 100% specificity and supporting its use in toxicology screening workflows.  

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Organ-Chips benefit toxicology studies at every step of the pipeline

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Early Discovery

Create custom organ models with closer-to-human gene expression to identify and validate drug targets

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Lead Optimization

Screen for diverse mechanisms of toxicity for preclinical drug candidates and assess the human relevance of toxicity observed in preclinical animal studies

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Preclinical Safety

Understand toxicity mechanisms to quantify risk and support "weight-of-evidence" arguments for entry into the clinic.

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Clinical Trials 

Identify the mechanism(s) of toxicity for candidates with unexpected safety signals in the clinic

Ready to advance your research with Organ-Chips?

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